Biochem/physiol Actions

Primary TargetPlasma and glandular kallikreins

Cell permeable: no

Reversible: no

Product does not compete with ATP.

General description

Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Inhibits the cleavage of atrial naturiuretic peptide (ANP 1-126) by kallikreins. Also inhibits adrenal kininogenase, a kallikrein-like enzyme.

Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Also available as a 10 mM solution in H₂O (Cat. No. 508573).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Byrne, R.E., and Scanu, A.M. 1989. J. Lipid Res. 30, 109.Scicli, G., et al. 1989. Adv. Exp. Med. Biol.247B, 217.Gibson, T.R., et al. 1987. Endocrinology120, 764.Kettner, G., and Shaw, E. 1981. Methods Enzymol.80, 826.

Packaging

10 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Sequence

H-D-Phe-Phe-Arg-chloromethylketone, 2TFA

Warning

Toxicity: Standard Handling (A)